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macrophage activation การใช้

ประโยคมือถือ
  • Subsequently, AIF1 may be an accurate indicator of macrophage activation in the body.
  • Type 2 have mutations in RAB27A and haemophagocytic syndrome, with abnormal T-cell and macrophage activation.
  • Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation.
  • These T cells can then go on to perform effector functions such as macrophage activation, B cell activation, and cell-mediated cytoxicity.
  • As is characteristic of Th1 axis lymphocytes producing inflammatory cytokines within thyroid tissue to further macrophage activation and migration into the thyroid gland for direct effect.
  • TGF-? is thought to play a role in alternative macrophage activation seen in lean mice, and these macrophages maintain an anti-inflammatory phenotype.
  • TIM3, an immune checkpoint, is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
  • Adult-onset Still's disease, some porphyrias, and hemophagocytic lymphohistiocytosis / macrophage activation syndrome are diseases in which the ferritin level may be abnormally raised.
  • Cytoplasmic localization of PELP1 upregulates pro-tumorigenic IKK? and secrete inflammatory signals, which through paracrine macrophage activation, regulate the migratory phenotype associated with breast cancer initiation.
  • C3a is an effector of the complement system with a range of functions including T cell activation and survival, angiogenesis stimulation, chemotaxis, mast cell degranulation, and macrophage activation.
  • For classical macrophage activation is necessary also lipopolysaccharide ( LPS )  typical for gram negative bacteria  which is mainly recognised by TLR4, or lipoteichoic acid ( LTA )  typical for gram positive bacteria.
  • Galectin-3 ( Gal-3 ) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis.
  • It is generated by ectodomain shedding of the membrane bound receptor . sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.